Another Pearl of Wisdom from PREMARIN Vaginal Cream. While you use it, it actually

restores vaginal tissue to help relieve vaginal dryness and

painful

intercourse.

If you’ve gone through menopause and are experiencing vaginal dryness and discomfort, you might want a treatment that works

beyond the surface. Menopause can cause changes in the vaginal tissues, causing uncomfortable symptoms. PREMARIN

Vaginal Cream can treat the underlying cause of these symptoms by restoring the tissues that support elasticity and provide

natural lubrication. And you don’t need to keep using it forever— just as long as you need treatment.

Important Safety Information

What is the most important information I should know about

• Using estrogen-alone may increase your chance of getting

•

cancer of the uterus (womb)

Report any unusual vaginal bleeding right away while you

•

are using PREMARIN Vaginal Cream. Vaginal bleeding

after menopause may be a warning sign of cancer of the

,

uterus (womb). Your healthcare provider should check

any unusual vaginal bleeding to find the cause.

• Do not use estrogen-alone to prevent heart disease, heart

attacks, strokes or dementia (decline in brain function)

• Using estrogen-alone may increase your chances of

•

getting strokes or blood clots

PREMARIN Vaginal Cream (an estrogen mixture)?

Using estrogen-alone may increase your chance of getting

dementia, based on a study of women 65 years or older

Do not use estrogens with progestins to prevent heart disease,

heart attacks, or dementia

1

Using estrogens with progestins may increase your chances of

getting heart attacks, strokes, breast cancer, or blood clots

1

Using estrogens with progestins may increase your chance

of getting dementia, based on a study of women age 65 years

or older

1

You and your healthcare provider should talk regularly about

whether you still need treatment with PREMARIN Vaginal Cream

PREMARIN® Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and painful intercourse

caused by these changes.

It should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack,

have or had blood clots or liver problems, are allergic to any of its ingredients, or think you may be pregnant. Most common side

effects include headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.

Please see Patient Information on following page.

PAY NO M O R E T H A N $ 1 5 FOR YO UR P R E S C R IP T IO N * BY V IS IT IN G P R E M A R IN V A G IN A L C R E A M .C O M

HELP R E LIE V E A N D R ESTO RE W H A T ’S YO URS

*Applies only to insured patients; cash-paying patients subject to a different discount rate. Certain other restrictions may apply. For more

information on these restrictions, visit PREMARINVAGINALCREAM.COM.

265628-01 © 2 0 1 0 Pfizer Inc. All rights reserved. April 2010